IL-12 RB1 Genetic Variants Contribute to Human Susceptibility to Severe Acute Respiratory Syndrome Infection among Chinese
Identifieur interne : 003181 ( Main/Exploration ); précédent : 003180; suivant : 003182IL-12 RB1 Genetic Variants Contribute to Human Susceptibility to Severe Acute Respiratory Syndrome Infection among Chinese
Auteurs : Fang Tang [République populaire de Chine] ; Wei Liu [République populaire de Chine] ; Fang Zhang [République populaire de Chine] ; Zhong-Tao Xin [États-Unis] ; Mao-Ti Wei [République populaire de Chine] ; Pan-He Zhang [République populaire de Chine] ; Hong Yang [République populaire de Chine] ; Hinh Ly [États-Unis] ; Wu-Chun Cao [République populaire de Chine]Source :
- PLoS ONE [ 1932-6203 ] ; 2008.
Abstract
Cytokines play important roles in antiviral action. We examined whether polymorphisms of interleukin (IL)-12 receptor
A case-control study was carried out in Chinese SARS patients and healthy controls. The genotypes of 4SNPs on
Comparison between patients and close contacts showed that individuals with the +1664 C/T (CT and TT) genotype had a 2.09-fold (95% confidence interval [CI], 1.90–7.16) and 2.34-fold (95% CI, 1.79–13.37) increased risk of developing SARS, respectively. For any of the other three polymorphisms, however, no significant difference can be detected in allele or genotype frequencies between patients and controls. Additionally, estimation of the frequencies of multiple-locus haplotypes revealed potential risk haplotypes (GCCT) for SARS infection.
Our data indicate that genetic variants of
Url:
DOI: 10.1371/journal.pone.0002183
PubMed: 18478121
PubMed Central: 2367437
Affiliations:
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Laboratory Medicine Department, Emory University School of Medicine, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pathology and Laboratory Medicine Department, Emory University School of Medicine, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Wei, Mao Ti" sort="Wei, Mao Ti" uniqKey="Wei M" first="Mao-Ti" last="Wei">Mao-Ti Wei</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Affiliated Hospital of APFCP Medical College, Tianjin, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Affiliated Hospital of APFCP Medical College, Tianjin</wicri:regionArea><placeName><settlement type="city">Tianjin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Pan He" sort="Zhang, Pan He" uniqKey="Zhang P" first="Pan-He" last="Zhang">Pan-He Zhang</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>State Key Laboratory of Pathogen and Biosecurity, Beijing, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yang, Hong" sort="Yang, Hong" uniqKey="Yang H" first="Hong" last="Yang">Hong Yang</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Ly, Hinh" sort="Ly, Hinh" uniqKey="Ly H" first="Hinh" last="Ly">Hinh Ly</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Pathology and Laboratory Medicine Department, Emory University School of Medicine, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pathology and Laboratory Medicine Department, Emory University School of Medicine, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Cao, Wu Chun" sort="Cao, Wu Chun" uniqKey="Cao W" first="Wu-Chun" last="Cao">Wu-Chun Cao</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, 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of Microbiology and Epidemiology, Beijing, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Liu, Wei" sort="Liu, Wei" uniqKey="Liu W" first="Wei" last="Liu">Wei Liu</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>State Key Laboratory of Pathogen and Biosecurity, Beijing, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Fang" sort="Zhang, Fang" uniqKey="Zhang F" first="Fang" last="Zhang">Fang Zhang</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xin, Zhong Tao" sort="Xin, Zhong Tao" uniqKey="Xin Z" first="Zhong-Tao" last="Xin">Zhong-Tao Xin</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Pathology and Laboratory Medicine Department, Emory University School of Medicine, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pathology and Laboratory Medicine Department, Emory University School of Medicine, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Wei, Mao Ti" sort="Wei, Mao Ti" uniqKey="Wei M" first="Mao-Ti" last="Wei">Mao-Ti Wei</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Affiliated Hospital of APFCP Medical College, Tianjin, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Affiliated Hospital of APFCP Medical College, Tianjin</wicri:regionArea><placeName><settlement type="city">Tianjin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Pan He" sort="Zhang, Pan He" uniqKey="Zhang P" first="Pan-He" last="Zhang">Pan-He Zhang</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>State Key Laboratory of Pathogen and Biosecurity, Beijing, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yang, Hong" sort="Yang, Hong" uniqKey="Yang H" first="Hong" last="Yang">Hong Yang</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Ly, Hinh" sort="Ly, Hinh" uniqKey="Ly H" first="Hinh" last="Ly">Hinh Ly</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Pathology and Laboratory Medicine Department, Emory University School of Medicine, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pathology and Laboratory Medicine Department, Emory University School of Medicine, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Cao, Wu Chun" sort="Cao, Wu Chun" uniqKey="Cao W" first="Wu-Chun" last="Cao">Wu-Chun Cao</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>State Key Laboratory of Pathogen and Biosecurity, Beijing, People's Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Cytokines play important roles in antiviral action. We examined whether polymorphisms of interleukin (IL)-12 receptor <italic>B</italic>1 (<italic>IL-12RB1)</italic> affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS).</p></sec><sec><title>Methods</title><p>A case-control study was carried out in Chinese SARS patients and healthy controls. The genotypes of 4SNPs on <italic>IL-12 RB1</italic> gene, +705A/G,+1158T/C, +1196G/C and +1664 C/T, were determined by PCR-RFLP. Haplotypes were estimated from the genotype data using the expectation-maximisation algorithm.</p></sec><sec><title>Results</title><p>Comparison between patients and close contacts showed that individuals with the +1664 C/T (CT and TT) genotype had a 2.09-fold (95% confidence interval [CI], 1.90–7.16) and 2.34-fold (95% CI, 1.79–13.37) increased risk of developing SARS, respectively. For any of the other three polymorphisms, however, no significant difference can be detected in allele or genotype frequencies between patients and controls. Additionally, estimation of the frequencies of multiple-locus haplotypes revealed potential risk haplotypes (GCCT) for SARS infection.</p></sec><sec><title>Conclusions</title><p>Our data indicate that genetic variants of <italic>IL12RB1</italic>confer genetic susceptibility to SARS infection, but not necessary associated with the progression of the disease in Chinese population.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, Yl" uniqKey="Lau Y">YL Lau</name></author><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Booth, Cm" uniqKey="Booth C">CM 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C">C Fieschi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sakai, T" uniqKey="Sakai T">T Sakai</name></author><author><name sortKey="Matsuoka, M" uniqKey="Matsuoka M">M Matsuoka</name></author><author><name sortKey="Aoki, M" uniqKey="Aoki M">M Aoki</name></author><author><name sortKey="Nosaka, K" uniqKey="Nosaka K">K Nosaka</name></author><author><name sortKey="Mitsuya, H" uniqKey="Mitsuya H">H Mitsuya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leal, S M" uniqKey="Leal S">S.M Leal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Ck" uniqKey="Wong C">CK Wong</name></author><author><name sortKey="Lam, Cw" uniqKey="Lam C">CW Lam</name></author><author><name sortKey="Wu, Ak" uniqKey="Wu A">AK Wu</name></author><author><name sortKey="Ip, Wk" uniqKey="Ip W">WK Ip</name></author><author><name sortKey="Lee, Nl" uniqKey="Lee N">NL Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kennedy, Mk" uniqKey="Kennedy M">MK Kennedy</name></author><author><name sortKey="Picha, Ks" uniqKey="Picha K">KS Picha</name></author><author><name sortKey="Shanebeck, Kd" uniqKey="Shanebeck K">KD Shanebeck</name></author><author><name sortKey="Anderson, Dm" uniqKey="Anderson D">DM Anderson</name></author><author><name sortKey="Grabstein, Kh" uniqKey="Grabstein K">KH Grabstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manetti, R" uniqKey="Manetti R">R Manetti</name></author><author><name sortKey="Gerosa, F" uniqKey="Gerosa F">F Gerosa</name></author><author><name sortKey="Giudizi, Mg" uniqKey="Giudizi M">MG Giudizi</name></author><author><name sortKey="Biagiotti, R" uniqKey="Biagiotti R">R Biagiotti</name></author><author><name sortKey="Parronchi, P" uniqKey="Parronchi P">P Parronchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Reeth, K" uniqKey="Van Reeth K">K Van Reeth</name></author><author><name sortKey="Van Gucht, S" uniqKey="Van Gucht S">S Van Gucht</name></author><author><name sortKey="Pensaert, M" uniqKey="Pensaert M">M Pensaert</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region><settlement><li>Pékin</li><li>Tianjin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Tang, Fang" sort="Tang, Fang" uniqKey="Tang F" first="Fang" last="Tang">Fang Tang</name></noRegion><name sortKey="Cao, Wu Chun" sort="Cao, Wu Chun" uniqKey="Cao W" first="Wu-Chun" last="Cao">Wu-Chun Cao</name><name sortKey="Cao, Wu Chun" sort="Cao, Wu Chun" uniqKey="Cao W" first="Wu-Chun" last="Cao">Wu-Chun Cao</name><name sortKey="Liu, Wei" sort="Liu, Wei" uniqKey="Liu W" first="Wei" last="Liu">Wei Liu</name><name sortKey="Wei, Mao Ti" sort="Wei, Mao Ti" uniqKey="Wei M" first="Mao-Ti" last="Wei">Mao-Ti Wei</name><name sortKey="Yang, Hong" sort="Yang, Hong" uniqKey="Yang H" first="Hong" last="Yang">Hong Yang</name><name sortKey="Zhang, Fang" sort="Zhang, Fang" uniqKey="Zhang F" first="Fang" last="Zhang">Fang Zhang</name><name sortKey="Zhang, Pan He" sort="Zhang, Pan He" uniqKey="Zhang P" first="Pan-He" last="Zhang">Pan-He Zhang</name></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Xin, Zhong Tao" sort="Xin, Zhong Tao" uniqKey="Xin Z" first="Zhong-Tao" last="Xin">Zhong-Tao Xin</name></region><name sortKey="Ly, Hinh" sort="Ly, Hinh" uniqKey="Ly H" first="Hinh" last="Ly">Hinh Ly</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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